Endocrine Abstracts

We showed previously that a single dose of ethanol acts as a stressor in female rats (Milovanovic et al., 2003). In order to extend this observation, we investigated whether the effect of ethanol on ACTH is dose-related and possible interactions between nitric oxide (NO) and alcohol on the level of ACTH. To this end, adult female Wistar rats showing diestrus day 1 were treated with: (a) ethanol (2 or 4 g/kg, i.p.), (b) Nω-nitro-L-arginine-methyl ester (L-NAME), whi...

Ghrelin is stored alongside glucagon in developing islet, although in a discrete cellular compartment, the pancreatic ε-cell. However, recent observations have shown a subpopulation of ghrelin/glucagon-double-positive cells in developing pancreas. The aim of the present study was to examine the developmental patterns of ghrelin- and glucagon-immunoreactive (ir) cells expression and possible co-localization of these hormones during human pancreas development. For this purp...